Our work in the nine-story UNMC Eppley Science Hall included the replacement of the existing exhaust systems for all of the laboratory fume hoods, as well as the replacement of the HVAC systems in all of the laboratory spaces and corridors. This work was completed in a fully occupied building. Additionally, the building is located in a very active and dense portion of the campus, immediately adjacent to the Eppley Cancer Institute and across the drive from an operating hospital. We coordinated the construction schedule with UNMC, shutting down 3-4 rooms at a time while creating swing space for the occupants to move into during the time it took us to complete the work in each block of rooms. We completed all disruptive work during building off-hours. These innovative and well-coordinated strategies were necessary to install reinforcing structural steel and new exhaust units on the roof, while our creative solutions to working in an occupied building kept the project on schedule, enhanced safety, and minimized conflicts with activities in the building.